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KMID : 1044520240870010065
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Tuberculosis and Respiratory Diseases
2024 Volume.87 No. 1 p.65 ~ p.79
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Roles of Inflammatory Biomarkers in Exhaled Breath Condensates in Respiratory Clinical Fields
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Choi Yong-Jun
Lee Min-Jae
Byun Min-Kwang
Park Sang-Ho
Park Ji-Myung
Park Dong-Il
Kim Sang-Hoon
Kim Young-Sam
Lim Seong-Yong
Yoo Kwang-Ha
Jung Ki-Suck
Park Hye-Jung
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Abstract
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Background: Exhaled condensates contain inflammatory biomarkers; however, theirroles in the clinical field have been under-investigated.
Methods: We prospectively enrolled subjects admitted to pulmonology clinics. Wecollected exhaled breath condensates (EBC) and analysed the levels of six and 12biomarkers using conventional and multiplex enzyme-linked immunosorbent assay, respectively.
Results: Among the 123 subjects, healthy controls constituted the largest group (81participants; 65.9%), followed by the preserved ratio impaired spirometry group (21patients; 17.1%) and the chronic obstructive pulmonary disease (COPD) group (21patients; 17.1%). In COPD patients, platelet derived growth factor-AA exhibited strongpositive correlations with COPD assessment test (ρ=0.5926, p=0.0423) and COPD-specificversion of St. George’s Respiratory Questionnaire (SGRQ-C) score (total, ρ=0.6725,p=0.0166; activity, ρ=0.7176, p=0.0086; and impacts, ρ=0.6151, p=0.0333). GranzymeB showed strong positive correlations with SGRQ-C score (symptoms, ρ=0.6078,p=0.0360; and impacts, ρ=0.6007, p=0.0389). Interleukin 6 exhibited a strong positivecorrelation with SGRQ-C score (activity, ρ=0.4671, p=0.0378). The absolute serum eosinophiland basophil counts showed positive correlations with pro-collagen I alpha 1(ρ=0.6735, p=0.0164 and ρ=0.6295, p=0.0283, respectively). In healthy subjects, forcedexpiratory volume in 1 second (FEV1)/forced vital capacity demonstrated significantcorrelation with CC chemokine ligand 3 (CCL3)/macrophage inflammatory protein 1alpha (ρ=0.3897 and p=0.0068). FEV1 exhibited significant correlation with CCL11/eotaxin(ρ=0.4445 and p=0.0017).
Conclusion: Inflammatory biomarkers in EBC might be useful to predict quality of lifeconcerning respiratory symptoms and serologic markers. Further studies are needed.
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KEYWORD
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Exhaled Condensates, Chronic Obstructive Pulmonary Disease, Lung Function Test, Eosinophils
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